Discoveries at Risk
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Clinical impact of recent genetic discoveries in osteoporosis
Osteoporotic fracture carries an enormous public health burden in terms of mortality and morbidity. Current approaches to identify individuals at high risk for fracture are based on assessment of bone mineral density and presence of other osteoporosis risk factors. Bone mineral density and susceptibility to osteoporotic fractures are highly heritable, and over 60 loci have been robustly associa...
متن کاملStatistical inference and data mining: false discoveries control
Data Mining is characterised by its ability at processing large amounts of data. Among those are the data ”features”variables or association rules that can be derived from them. Selecting the most interesting features is a classical data mining problem. That selection requires a large number of tests from which arise a number of false discoveries. An original non parametric control method is pr...
متن کاملEditorial Report of fifteen years contributions to radiological sciences: Future directions and prospects
At the close of the 20th century, fundamental discoveries changed broadly the worlds of physics, biology and medicine. The rapid advancements achieved during recent years, mainly due to revolutionary methodological improvements, have led to an unparalleled explosion of information; often appear to overshadow the earlier works. However as more basic discoveries are made these separate scientific...
متن کاملSafety and Efficacy of Bevacizumab in High-Risk Corneal Transplant Survival Principal Investigator: DANA, REZA Institution Receiving Award: MASSACHUSETTS EYE AND EAR INFIRMARY Program: DMRDP
Rationale and Objective: There is an increasing divide between basic and preclinical science on the one hand, and clinical care on the other. Indeed, the vast majority of important discoveries in science over the past decade that could have therapeutic benefits are not close to clinical application, or even clinical trials. Translational efforts are absolutely necessary to test "proof-of-concep...
متن کاملEvaluation of verbal evidence on the prohibition of Human Cloning
Human cloning or human reproduction through nonsexual transplantation is an interdisciplinary issue that has been discussed by researchers from different dimensions, including theological dimension and perspective of science, religion, and health. Since some scientific discoveries, such as human simulation, are related to human beliefs, several religious scholars have shown special sensitivity ...
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